Endocrine Abstracts

Aim: In this study, we aimed to evaluate ABO blood groups and Rh factor in patients with thyroid cancer. We also assessed whether the ABO/Rh factor had any effect on prognosis, agressive features and advanced stage of thyroid malignancies.Methods: Medical records of patients who underwent thyroidectomy between December 2006 and September 2014 were evaluated retrospectively. Demographical and clinical features, cytological results (according to Bethesda c...

The control of the onset of human puberty remains an enigma. According to current understanding, the ‘GnRH pulse generator’, a functionally interconnected and synchronized network of GnRH neurons, is inhibited throughout childhood following a period of pubertal level activity during fetal life. Release of this inhibition at the early second decade of life signifies the reawakening of the pulse generator.Recently, we have identified loss-of-func...

Mammalian pregnancy is characterized by tremendous changes and adaptations in the endocrine as well as in the immune system. Early in pregnancy, levels of female sex hormones, progesterone (P4) and estradiol (E2) produced by the corpora lutea (CL) significantly rise, promoting huge modifications of the uterine epithelium ensuring embryo implantation. Once the embryo is implanted, trophoblast cells produce and release increasing levels of human chorionic g...

Objective: Sperm cells are produced in the testes by the Sertoli cells. These cells produce Inhibin B too and they are stimulated by FSH. Can Inhibin B be a good marker of spermatogenesis? Should we use other marker (FSH?, testosterone?)Design: Prospective study.Patients: We examined 56 patients with infertility.Methods: Semen analysis and hormonal analysis was performed. Semen analysis was performed accordin...

Fetuin-B is an inhibitor of basic calcium phosphate, preventing unwanted calcification. The low level of fetuin could be associated with an increased risk of atherosclerosis and ectopic microcalcifications in soft tissues and the rupture of the membranes leading to preterm delivery. Our aims were i) to examine the alterations of mRNA expression of the fetuin-B in the late pregnant rat uterus, furthermore ii) to investigate the fetuin-B expression in hormonally- and lipopolysac...

The excess androgen levels in women with PCOS may be ovarian and/or adrenal in origin and one proposed contributing mechanism is an alteration in cortisol metabolism. Increased peripheral cortisol metabolism, either by enhanced inactivation of cortisol by 5alpha-reductase or impaired reactivation of cortisol by 11b-hydroxysteroid dehydrogenase (11bHSD type 1), results in decreased negative feedback suppression of ACTH secretion maintaining normal plasma cortisol concentrations...

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Introduction: Pseudohypoparathyroidism (PHP) is a rare disorder characterized by parathormone (PTH) resistance, caused primarily by genetic defects involving the alpha-subunit of the stimulatory G protein. Biochemical and molecular analysis classify pseudohypoparathyroidism into types I-a, I-b, I-c and 2. We report a case of PHP I-b in an adolescent presenting with a neurological disorder.Case Report: 11 years old female patient, with no relevant persona...

Osteoporosis and Fracture: The Role of the Endocrine NurseThe importance of osteoporosis lies in the increased fracture risk associated with reduced bone mineral density (BMD). Although osteoporosis is not painful, osteoporotic fractures are associated with significant morbidity and mortality; furthermore the occurrence of a fracture leads to an increased risk of subsequent fracture in both women and men.Identification of patients ...

Particulate guanylyl cyclases are expressed in all endocrine organs and serve as specific receptors of the natriuretic peptides ANP, BNP and CNP. Guanylyl cyclase-B (GC-B/Npr2) receptors specifically mediate the biological effects of CNP in its target tissues. Targeted disruption of either CNP or GC-B results in pituitary growth hormone deficiency and dwarfism as a result of achondroplasia. Despite this, molecular regulation of GC-B expression is poorly elucidated. Therefore, ...